Ethical Genomic Research and DNP 810 Discussions

Ethical Genomic Research and DNP 810 Discussions

Ethical Genomic Research and DNP 810 Discussions

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Abstract: Integration of genomic technology into healthcare settings establishes new capabilities to predict disease susceptibility and optimize treatment regimes. Yet, Indigenous peoples remain starkly underrepresented in genetic and clinical health research and are unlikely to benefit from such efforts. To foster collaboration with Indigenous communities, we propose six principles for ethical engagement in genomic research: understand existing regulations, foster collaboration, build cultural competency, improve research transparency, support capacity building, and disseminate research findings. Inclusion of underrepresented communities in genomic research has the potential to expand our understanding of genomic influences on health and improve clinical approaches for all populations. 

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Topic 1 DQ 1

Name three essential structural elements of a functional eukaryotic chromosome and describe their functions. Discuss the implications related to research, health, and life span in terms of one of the structural elements.

Topic 5 DQ 1

Describe one health issue and discuss how nutrition can impact this health issue positively and negatively.

Topic 1 DQ 2

Describe the difference among replication, transcription, and translation for both DNA and RNA.

DNP 810 Topic 2 Discussions:

DQ 1 Describe at least four factors that can be associated in a complex inheritance health issue.

DQ 2 Compare two genomic tests used for screening, diagnosis, and management of a disease. Describe whether outcome data exists related to the utility of these tests and what the data shows, if available.

Topic 3 DQ 1 Contrast two models used for multigenerational family health histories. Which do you prefer and why?

Topic 8 DQ 2

Choose one recent (within last 2 years) news story about genetic or genomic technology. Describe the issue presented. From the perspective as an RN or APRN, describe the ethical, cultural, religious, legal, fiscal, and societal implication.

Topic 3 DQ 2 Describe the importance of a comprehensive health and physical assessment that includes information on environment, and genomic influences. Frame this answer through your current role, whether as an Advanced Registered Nurse Practitioner (ARNP) with a practice, or a nurse executive overseeing nursing practice in an organization.

DNP 810 Topic 4 discussions:

DQ 1 Genetics testing is viewed as either positive or negative. When used to detect the genes for breast cancer, health insurance companies deny care based on genetics. Why? Describe one genetic test and its impact on health, prevention, screening, diagnostics, treatment selection, and treatment effectiveness.

DQ 2 Evidence-based practice and standardized clinical guidelines have improved organizations and the ability of providers to provide the care with the highest level of evidence to each patient. Describe one pharmacological agent with a protocol/clinical guideline that is used. Discuss how this protocol may not take into consideration genetic variations. What can be done to tailor care to each patient while providing standardized treatments?

DNP 810 Topic 5 DQ 2

Choose one disorder of malnutrition. Discuss the genetic and environmental influences on this disorder, including prevalence rates, testing, treatment, and prognosis.

Topic 6 DQ 1 Discuss how genetic and genomics can play a role in a demand for new health services and how it may impact health care expenditures in the aging population. Give one example.

Topic 6 DQ 2 Describe one method that includes using evidence-based data to support a new or innovative ways to care for the aging now or in the future. How will it impact care and what are the anticipated outcomes? Ethical Genomic Research and DNP 810 Discussions

DNP 810 Topic 7 DQ 1

Discuss how genetic and genomics can play a role in a demand for new health services and how it may impact health care expenditures in the chronic disease population. Give one example.

DNP 810 Topic 7 DQ 2

Describe one method that includes using evidence-based data to support a new or innovative way to care for those with chronic disease now or in the future. How will it impact care and what are the anticipated outcomes?

Topic 8 DQ 2

Describe two issues that undermine the rights of clients in genetic- and genomic-related decision making and action. Discuss a potential solution for each as well as your role in this issue as the patient advocate. Ethical Genomic Research and DNP 810 Discussions

A framework for enhancing ethical genomic research with Indigenous communities

Introduction

The integration of genomics into healthcare has advanced the ability of researchers and clinicians to predict disease susceptibility and optimize treatment regimens that have the potential to reduce the risk of certain diseases. Routine genome sequencing has become possible with the expanded availability and affordability of next-generation sequencing technology. Recent initiatives such as the All of Us research program seek to advance health data integration by collecting genetic information and medical and lifestyle histories from one million individuals (https://allofus.nih.gov/). However, Indigenous peoples, including American Indians (AI), Alaska Natives (AN), and Native Hawaiians (NH), remain underrepresented and understudied in genetic and clinical health research1,2,3, despite facing disproportionately higher rates of cardiovascular disease (CVD), cancer, diabetes, and infectious disease compared with non-Hispanic whites4,5. Large-scale research consortia such as the eMERGE Network, CSER, and the International HapMap consortia6,7,8 have successfully recruited only few, if any, Indigenous individuals despite attempts to achieve a representative sample. In fact, despite a numerical increase in participants, the percentage of Indigenous people represented in genome-wide association studies worldwide decreased from 0.06% to 0.05% between 2009 and 20161,9. As such, they are less likely to benefit from genomic research seeking to elucidate the biological etiology of disease, which could aid in disease prevention and treatment and reduce future healthcare disparities10.

Globally, Indigenous people are underrepresented in genomic research studies for a variety of reasons including researchers’ failure to engage Indigenous communities in ethical and inclusive ways, lack of study transparency, and historical and recent research malpractice11,12,13, all of which have sowed mistrust and justified peoples’ unwillingness to share personal health information, including DNA, with the research community. We briefly describe two examples of research misconduct and lapses in research ethics. First, the Human Genome Diversity Project (HGDP) and subsequent large-scale efforts such as the National Genographic Project began as endeavors to study worldwide human genetic diversity and global migration patterns. However, these projects failed to fully consider the damaging social and political implications to Indigenous communities that, in the case of the HGDP, prompted strong resistance by the Indigenous Peoples’ Council on Biocolonialism (http://www.ipcb.org/) and tarnished future trust in research and researchers14,15,16. Second, the Havasupai Tribe filed a lawsuit against the Arizona Board of Regents over lack of informed consent and a violation of civil rights in addition to unapproved genetic research with DNA samples17,18,19. The case raised awareness of cultural and political sensitivities around what constitutes appropriate research20. These two examples have raised concerns about the negative impacts that research harms (e.g., stigmatization, violation of individuals’ rights, lack of benefit, and cultural incongruence) can have on Indigenous communities.

Despite decades of scientific transgressions across the globe, many Indigenous communities worldwide continue to be interested in genetic research. Some Indigenous communities have developed their own policies to promote responsible conduct of research and have created research review boards to implement mechanisms of accountability that position themselves as partners in research. Some voices within biomedical research have advocated for approaches centered on creating active roles for research participants, community consultation, and research transparency with Indigenous communities—themes embedded in a community-based participatory research (CBPR) approach14,21,22,23. In one case, the San people of Southern Africa, who have been a focal point of genetic research for over 60 years (more recently with a focus on whole-genome studies)24,25,26, issued a code of ethics in early 2017 for researchers conducting studies with their communities27. This step was prompted by concerns over the use of insulting terminology in reference to the community, failure to communicate findings to the community, direct recruitment without governance authority, and a lack of investment in the community28,29. In other cases, research guidelines such as Te Mata Ira: Guidelines for Genomic Research with Maori in New Zealand and the Human Heredity and Health (H3Africa) Guidelines for Community Engagement in Africa have empowered Indigenous communities to seek positive outcomes from genomic research30,31,32. Furthermore, the Navajo Nation in the United States (US) has begun to develop a strong culturallyinformed genetic research policy in place of an existing 16-year moratorium on genetic research33. Importantly, these emerging guidelines arose from active and frequent communication between researchers (including Indigenous researchers) and community members over many years comprised of multiple training workshops, community meetings, and development of digital and print informational materials. Such efforts to bridge the divide between genomic research and Indigenous peoples will likely alleviate tensions and concerns34. While these examples highlight the ongoing concerns of global Indigenous communities, we offer potential solutions to achieve greater equity in genetic research.

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The six principles

Ethical framework

As Indigenous scientists and allies of the Summer internship for INdigenous peoples in Genomics (SING) Consortium35 and also as members of our own tribal communities, we recognize the potential for Indigenous communities to benefit from genomic research. Over the past 2 years, we developed this framework in which we propose the following set of principles (Fig. 1 and Table 1), informed by CBPR approaches, to engage Indigenous people and communities in genomic research. This framework includes six principles: (1) understand existing regulations, (2) foster collaboration, (3) build cultural competency, (4) improve transparency, (5) support capacity, and (6) disseminate research findings. The goals of the framework are to build trust, increase inclusion of diverse groups in genomic research, and enhance ethical research practices that promote tribal research regulations (e.g., tribal oversight and consultation) and benefits to participants and their communities. Our ethical framework extends beyond the current US federal requirements for biomedical and behavioral research (as described by the recently revised Common Rule36), which draws upon the principles of bioethics (respect for persons, beneficence, and justice from the Belmont Report), and community-engaged research.

Fig. 1
Ethical Genomic Research and DNP 810 Discussions

An ethical framework for enhancing genomic research with Indigenous communities. The recognition of tribal sovereignty and research regulations are at the core of our ethical framework. Moving outward from the center, community engagement is necessary to build a foundation to create a collaborative partnership among researchers and community members. Starting from the right going clockwise, researchers should incorporate cultural competency, transparency, capacity building, and dissemination strategies to build trust, increase inclusion of diverse groups in genomic research, and enhance ethical research practices. The diagonal words represent core values that should be used throughout the research process.

Table 1 Principles for engaging in ethical research with Indigenous people

Although we focus primarily on Indigenous groups of the US (AI, AN, and NH), this framework can inform research practices in many Indigenous communities to incorporate cultural views and acknowledge local research review boards. Few studies have engaged Indigenous communities in genomic research, yet some supportive research collaborations guided by CBPR principles have been ongoing for decades and can serve as examples of what is possible. We illustrate the principles listed below with examples of genetic research with tribes, and highlight how studies have effectively incorporated some of the principles that we present in our ethical framework. Thus, we provide this framework to promote inclusion of historically underrepresented communities in future genomic research, which will expand genomic and health knowledge for diverse populations37,38.

Understand tribal sovereignty and research regulation

Within the US, interactions between researchers and Indigenous people require attention to political considerations as well as the ethical considerations described above. We focus on AI/AN tribes in the US and recognize they are distinct from other underrepresented minorities and global Indigenous groups in that the US government recognizes tribes as domestic-dependent nations and many tribal nations function as sovereign entities (i.e., an autonomous government with the authority to govern and uphold a range of laws including research codes)39; however, Native Hawaiians and some US-based tribes remain unrecognized at the state and federal levels40,41. In research endeavors involving AI/AN tribes or tribal members, researchers must recognize any existing tribal sovereignty or local governance structures (e.g., the local laws and regulations) before engaging in research42. This recognition should be extended to all Indigenous groups regardless of federal or state recognition, as they are distinct and cohesive communities who possess their own social and cultural infrastructures.

Many tribes have regulatory research review structures that may include their community-guided Institutional Review Board (IRB) (e.g., tribal, Indian Health Service (IHS), or healthcare corporation IRB) or tribal councils from which researchers will have to seek approval in addition to their university IRBs. The local review boards (e.g., community IRB or committee) oversee research protocols and may dictate the types of required consent, data and sample usage, and dissemination of research findings in particular communities. Within the US, there are currently 25 IRBs serving tribes and urban Indian communities that are registered with the US Department of Health and Human Services (https://www.ihs.gov/dper/research/hsrp/instreviewboards/). Some IRBs, such as the intertribal Rocky Mountain/Great Plains Tribal Region IRB have created rigorous regulations that promote Indigenous values and community participation for collaborating researchers and serve multiple independent tribes43. There is strong support among tribes for “data-sharing procedures that take into account tribal sovereignty and appropriate oversight of research,”44 which would be under the purview of the tribal IRBs or research review boards. Policies relating to biospecimen handling and ownership, data storage, and the ultimate return or destruction of samples should be developed early in the research process in collaboration with the local oversight structures. Ethical Genomic Research and DNP 810 Discussions

Engage and collaborate with the tribal community

To best promote respectful and mutually beneficial research, it is important to recognize the role of historical and current social, political, economic, and environmental influences on health. A comprehensive approach to research that utilizes elements of “community-based research” (also known as community-engaged research) integrates many of these factors45,46. Community-based approaches have enhanced research with diverse populations in public health and the social sciences, and the approach has also been endorsed by researchers, funding agencies, and national organizations47. Utilizing these approaches, researchers can carefully design studies to build long-term partnerships/collaborations that acknowledge Indigenous peoples’ longstanding knowledge systems and tribal sovereignty (if applicable), account for variables within studies that are not obvious to researchers, and honor Indigenous community values in a culturally respectful manner.

Engaging the community in research can occur at various levels and take many forms. To facilitate community involvement, it is crucial to develop an engagement plan for the research study before its onset and to develop engagement activities for all phases of research. Discussing all aspects of a research study with Indigenous community members and involving them, from the conceptual design to data analysis to the conclusions, can positively impact the research by identifying priority topic areas and questions that are relevant to the community. This, in turn, can generate innovative ideas, more robust hypotheses, and reduce scientific biases. Integrating Indigenous knowledge and perspectives in the research process could be particularly valuable for the analysis, interpretation, and dissemination of the study results.

Building relationships with community members throughout the study increases the likelihood of successfully completing the study and the possibility of developing subsequent long-term partnerships. Collaboration builds trust and can enhance research participation throughout the study’s duration. In some tribal partnerships, one favorable engagement activity has been to implement a tribal advisory council that meets regularly to provide feedback about the ongoing studies and fosters educational opportunities for all participating entities48.

The Center for Alaska Native Health Research (CANHR) team incorporated principles of CBPR throughout the initiation and development of their center, with researchers initially generating the questions and then approaching the community partners to determine which questions were of interest49. The research questions, study methodology, and dissemination plan were continually refined to reflect community interests through an iterative process of communication and collaboration with a community advisory group (CAG) that ultimately settled on investigations of obesity and diabetes. In particular, the genetic component of the study necessitated the creation of a space for discussing genetic topics between tribal partners and CANHR researchers. The research team utilized the Genetic Education for Native Americans program to conduct a 2-day workshop about basic cell biology, risks and benefits of genetic research, and cultural considerations50. The resulting strong collaborative relationship is essential to the longstanding success of the CANHR partnership with tribal communities. Ethical Genomic Research and DNP 810 Discussions

Build cultural competency

Cultural competency is the ability to acknowledge, communicate, and understand cultural differences while interacting effectively with individuals across cultures. Striving to attain cultural competency is essential for researchers to work toward understanding a community’s cultural values and norms. Researchers should enter Indigenous communities with humility, empathy, and willingness to listen and learn. Without adequate cultural competency in a research project, Indigenous communities may feel that their perspectives and knowledge are devalued or not respected. In particular with biological specimen collection, many Indigenous groups feel that their blood and other tissue samples remain contiguous with the spiritual and physical person throughout their life51. In addition, understanding the social, cultural, and structural determinants of health within Indigenous communities (e.g., poverty, barriers to education and employment, and cultural traditions that foster resiliency) is important for contextualizing interactions with the community, creating project objectives, interpreting results, and conducting culturally sustainable science. Therefore, sensitivity to community values, worldviews, restrictions, social circumstances, and the social and economic structures must be practiced when proposing a genomic research study.

Cultural competency also entails working alongside partners with different skills and worldviews. Spending time in the community and being visibly present, through formal research planning meetings and participation in community events, is critical to understand their perspectives, questions, and concerns and for developing relationships. These interactive approaches may allow researchers to identify an appropriate cultural adviser who can aid in navigating the community dynamics. Various resources exist for cultural competency and ethics training for researchers intending to engage with Indigenous communities. There are online and in-person resources for cultural competency training through the Association of American Medical Colleges Tool for Assessing Cultural Competence Training (TACCT). In addition, the National Congress of American Indians (NCAI) AI/AN Genetics Resource Guide (http://genetics.ncai.org) and the Collaborative Research Center for American Indian Health (CRCAIH) offer guidance for researchers to orient themselves to the broader tribal perspective52. More recently, the Ethics Training for Health in Indigenous Communities Study (ETHICS) created an alternative training option through the online Collaborative Institutional Training Initiative (CITI) research ethics training course that is tailored for federally-funded researchers working with AI/AN communities53. Building a culturally-adept foundation demonstrates respect and enables bidirectional communication, which can further fulfill community needs and provide an indigenized perspective for future research projects. Ethical Genomic Research and DNP 810 Discussions

An example of cultural competency integration in research is found in the Northwest-Alaska Pharmacogenomics Research Network (NWA-PGRN), a collaborative partnership between various research institutions and tribal organizations to study and improve drug response in AI/AN people54. The NWA-PGRN established a CAG within each of its participating tribal communities to initiate research on genomic-pharmaceutical drug interactions48,55. Central to this collaboration was a bidirectional flow of knowledge: CAG members instructed researchers in cultural competency, traditional knowledge, and science, while researchers conducted workshops and presentations on pharmacogenetics in a community setting (e.g., in the local community rather than at a research institution).

Improve transparency of research practices

Academic and community goals often differ, necessitating open communication between researchers and community members. To promote transparency, researchers should strive for clarity about the project’s goals in project documents (e.g., research protocol, recruitment materials, consent forms, research results, etc.) and use accessible language. Ideally, the materials should be deliberated upon and approved by community partners and their local review committees before they are disseminated, then revised with feedback as appropriate. Many Indigenous communities may decide to participate in research for the perceived benefits, even if the benefits are not yet realized. As such, researchers must be careful to avoid over-promising benefits from their studies. For example, results that are generated from genomic research often takes years to interpret and disseminate in ways that allow communities to benefit. Even if a new genetic test is produced, it may not offer a health benefit without proper treatment and prevention in place. In addition, if research goals change during the study, it is necessary to keep the community informed. When collected data spurs new hypotheses, the community should be engaged in the formulation of new research directions. To build understanding and trust, community partners can be invited into the laboratory and shown where samples are stored, how they are processed, and how the data are generated. Finally, the anticipated future use of data, samples, and long-term ownership/storage of sequence data must be discussed thoroughly before the study begins. To formalize partnerships, there are various examples of potential agreements such as a Memorandum of Understanding that should be considered by all parties involved and the future disposition of data and samples defined in a Materials Transfer Agreement or Data Sharing Agreement.

Ethical concerns and lack of transparency led some academic institutions to initiate moratoriums on research of archived Indigenous materials, as occurred at the Australian National University in the 1990s. Following this decision, the National Center for Indigenous Genomics (http://ncig.anu.edu.au/) was created in 2013 to regulate archived materials and promote genomic research of benefit to Indigenous Australians. The Center is under Indigenous governance, composed of an Indigenous-majority Board, who ensures Indigenous custodianship of biological samples, proper engagement, insight into research directions and programming, and dissemination of information.

Build tribal research capacity

Building tribal research capacity by which Indigenous scientists can lead research that is directly aligned with community values is essential for long-term culturally sustainable science. From 2004–2014, the percentages of doctoral degrees awarded annually in science and engineering to Indigenous people in the US was less than 0.4% (in 2014, 110 AI/AN and 33 NH out of 38,939 nationwide were awarded doctoral degrees), which highlights the disparity in the number of trained Indigenous researchers56,57. The participation of Indigenous people and other underrepresented minority populations in Science, Technology, Engineering and Mathematics (STEM) fields remains shockingly low, and Indigenous students often face various barriers that preclude them from pursuing or continuing careers in STEM fields57, such as inadequate academic preparation, competing family or cultural demands, conflicting epistemologies, income barriers, and poor mentorship. Allies in leadership positions at academic and federal institutions can play an important role in building research capacity to increase training opportunities for Indigenous scientists to conduct health and genomic studies within their communities. Therefore, the research community should actively work to continually train, engage, mentor, and support emerging Indigenous scientists from the trainee level to beyond the early career scientist stage.

Further tensions surrounding genomic research may stem from a disconnect between scientists and the Indigenous communities involved in research. Around the world, social and economic inequities have contributed to the lack of recruitment and inclusion of Indigenous people in genomic studies, education, and training. Indigenous people are more likely to live in locations distant from the universities and institutions conducting the research and thus may have less experience working with researchers. In closing this divide, Indigenous scientists can act as cultural brokers and serve as liaisons between their communities and academic research institutions with a capacity to lead future projects. Ultimately, a critical mass of Indigenous scientists can become self-sustaining, providing beneficial impact within both the broader scientific community and their own communities.

Building research capacity within Indigenous communities strengthens inclusivity in biomedical research and promotes the use of culturally appropriate frameworks. Inclusion of community and Indigenous researchers can bring greater transparency of the research process to Indigenous communities and provide training opportunities for them to become involved in the research. Those seeking guidance beyond local tribal governance may also contact the newly appointed Director of Tribal Health Research Office, which coordinates NIH research related to the health of AI/AN across the NIH Institutes, Centers, and Offices, and recently released a Tribal Consultation Policy (https://dpcpsi.nih.gov/thro).

An example of a study that has built research capacity in tribal communities is the Strong Heart Study (SHS). SHS was founded in 1988 to investigate CVD among 12 participating tribes across the country and stands as the largest epidemiological study to date among AIs and the second longest running study of CVD in the US58. Recent investigations focus on identifying genetic risk factors of CVD in participating families recruited from health centers and academic institutions59,60,61. To build trust across these distinct communities, SHS investigators worked closely with community leaders to identify specific questions of interest within the scope of the study and hired community members to work within the study group. Consequently, SHS maintains 90% retention rates across study phases and has incorporated dozens of AI/AN investigators who participate in active research teams, including the training of many Indigenous PhDs, MDs, nurses, and other medical professionals from tribal communities62. SHS has served as an important model for collaborative efforts with Indigenous groups. Ethical Genomic Research and DNP 810 Discussions

Disseminate findings in a community-accessible format

Research findings are usually published in academic journals, yet the publications are rarely accessible to Indigenous communities nor do they tend to enter the community discourse, thus limiting the impact to community knowledge and benefit. Soliciting community input regarding best practices to disseminate research findings to participating and affected communities can reverse this trend. Broadening the format of disseminated research results using creative solutions offers community partners greater access to the materials (e.g., digital storytelling, community newsletters or reports, social media, radio, and small grassroots interventions). For example, rural AN communities have used digital storytelling (culturallyimmersed videos) to share knowledge about health promotion and cancer awareness within their community63. Inspired by TED Talks, video-based content has also been developed through RED Talks, an online YouTube channel designed to share solution-based ideas, tribal research and policies, and success stories across tribes. With access to such information, communities can generate tool kits and further policies.

Acknowledging the contributions of community partners is imperative for strengthening partnerships. Researchers can do this by inviting community members who contributed in meaningful ways to the research process to be co-authors or acknowledging their contributions in publications, disseminated materials, or presentations. Lack of acknowledgment actively disengages partner communities from the research process, removing their insight, efforts, and work in the research process. At a minimum, communities should be included in the acknowledgements to indicate their central role in all completed studies. Ownership of the study is thus transferred back to the community while instilling added confidence in future research endeavors.

Our framework considerations are multifaceted and interconnected. Each research study will have different levels of collaboration and be unique in its own way. Depending on the Indigenous community, some research projects may need to apply only a few of the principles outlined above. Ultimately, the study goals and the dynamics of the community–researcher partnership will evolve throughout the duration of the project. Application of these principles, as demonstrated by collaborative genomic research projects such as those between the White Mountain Apache and the National Institutes of Health64, or the Maori tribes in New Zealand and the University of Otago (https://www.otago.ac.nz/full-circle/), suggest that research programs between Indigenous people and scientific communities can flourish when commitment and transparency are prioritized.

Future directions

The suggested framework requires deliberate investments in time and effort by researchers and Indigenous collaborators. Building strong and equal partnerships is necessary for establishing long-lasting successful relationships that have the potential to greatly benefit future research endeavors. Acknowledging the commitment required to incorporate these ethical principles of genetic research in Indigenous communities means new supportive policies and substantial investments from federal agencies and institutions will be necessary. Given that diversity in research is a top priority for many agencies and universities65,66, their commitment to this effort must be demonstrated by actions that enable and facilitate our framework for underrepresented communities. Without such policies, entire communities of Indigenous people will continue to be ignored, despite research programs’ best intentions.

Moving forward, genomic research partnerships between academic institutions and Indigenous peoples can be fostered by viewing participating groups as collaborators instead of research subjects. Presently, with the new All of Us research program, technological advancements, and increased awareness of enlightened research approaches, we have the opportunity to usher in an era of widespread respectful and beneficial research that has the potential to truly engage Indigenous and other underrepresented populations in genomic research. This framework offers an opportunity for researchers to begin working with Indigenous communities, which provides a richness of discoveries that are both scientifically and ethically motivated. As ethical researchers, we must strive to incorporate the presented framework into the current research paradigm and undertake this challenge of collaborating and engaging with Indigenous communities to address the health challenges faced by these communities. More broadly, other Indigenous communities can choose to use this framework to promote stronger engagement so that the benefits from scientific advances are distributed more meaningfully and equitably. Ethical Genomic Research and DNP 810 Discussions